The 6th congress of the French Society for Stem Cell Research was held in Paris from January 22 to 24.

Young researchers from the OuestOÏD network were present and presented their research work:

      • Julie Warin, of the research unit RMeS in Nantes (Group BIODIV “Stem Cells and Development of the Axial Skeleton”), presented during a oral communication his study on notochordal cells ("Deciphering microenvironment cues to maintain human notochordal cells phenotype and to drive their maturation toward adult disc cells»).
      • Sabrina Jagot, INRAE ​​units LPGP et Panther, was able to orally do the teasing his poster on trout muscle stem cells (« Distinct dynamics of muscle stem cell subtypes associated with the hyperplasia decline in trout »).

 

Two doctoral students agreed to tell us a little more about their posters:

  • Veranika Panasenkava, of the IGDR in Rennes (“Genetics of Developmental Pathologies” Team):

For his poster « Induced human pluripotent stem cells to improve diagnosis of shh-dependent midline brain defects "

« Holoprosencephaly (HPE) is a rare pathology of early brain development, often linked to dysfunctions of the Sonic Hedgehog (SHH) signaling pathway. Accurate molecular diagnosis is complex due to unavailability of affected primary tissue, thus requiring innovative methods. We used induced pluripotent stem cells to create an in vitro model of human neurectodermal tissue, similar to tissue affected by HPE. Through in-depth transcriptomic analysis, we identified signatures linked to SHH activity and discovered new genes potentially regulated by this pathway. This approach represents an advance in the molecular diagnosis of HPE, offering new horizons for the understanding of neurodevelopmental diseases."

👉 Poster to download

 

  • Eva Moinard, from CR2TI in Nantes (“Cell and gene engineering in tolerance, fertility and regenerative medicine” team) 

« I presented my poster “ Establishing a reference map of human embryo peri-implantation development“. We used a bioinformatics approach to find new markers of embryonic lineages at the time of implantation. It is a period of human development that is very poorly characterized. The markers were tested in stem cell models and then we validated them in human embryos in prolonged culture up to 11 days after fertilization. This allowed us to highlight the temporality of expression of these 3 transcription factors: ZIC3, TFAP2A and RXRA. At the same time, we formulated new hypotheses regarding the gene networks regulating trophectoderm cell fate with RXRA potentially regulating maturation and TFAP2A maintaining this fate. Finally, we refined the assimilation of primed and naive pluripotent stem cell models to the pre- and post-implantation epiblast. »

👉 Poster to download

 

Among the other posters on display: 

  • Lola Bonneau, Inserm UMR 1235 – TENS, Nantes: “Mechanisms of human digestive tract regionalization during embryonic development”
  • Simon Chevolleau, Center for Research in Transplantation and Translational Immunology (CR2TI), Nantes: “Pipeline to identify important cell fate drivers during development”
  • Anne Gaignerie, MicroPICell, Nantes: “Innovative imaging of organoids and embryos enables new analyzes options” 👉 link to poster
  • Ophélie Pierre, Laboratory Neural Keratinocyte Interactions (LINK/LINK), Brest: “Development of a reinnervated model of human skin with sensory neurons-like obtained from skin derived precursors”
Post Views: 3