GO-EV meeting on March 21, 2025 in Angers
On March 21, 88 participants with varied backgrounds met in the Larrey amphitheater in Angers for a scientific day dedicated to “Extracellular Vesicle Exploration Technologies”, organized by the GO-EV network.
A day marked by rich discussions, diverse approaches, and collective enthusiasm for EVs. This event showcased the expertise of technology core facilities, highlighted emerging projects, and fueled discussions on the network's prospects.
Relive the highlights in video:
The Angevin core facilities are vesiculating!
This session highlighted three Angers technology core facilities, which presented the cutting-edge tools available for studying extracellular vesicles (EVs):
Catherine Guillet and Jérôme Cayon (PACeM, Angers) opened the session with a presentation on the techniques available on the PACeM core facility for the study of extracellular vesicles. Their intervention allowed the discovery of the analytical capabilities offered locally, useful for the isolation, quantification and visualization of EVs.
Arnaud Chevrollier (SCIAM, Angers) then presented approaches for the identification and characterization of EVs, demonstrating their skill in advanced microscopy to explore these structures invisible to the naked eye and understand their biophysical properties.
François Guillonneau (Prot'ICO, Angers) closed this sequence with a presentation on the decoding the proteomic cargo of EVs and the pitfalls to avoid during purifications. His feedback has sparked numerous discussions on the methodological challenges associated with the detailed analysis of vesicle contents.
These presentations highlighted the potential of Angers' technological core facilities, their expertise and their ability to meet expectations related to extracellular vesicles.
GO-EV Members' Short Talks
The morning continued with short presentations, highlighting the diversity of subjects and approaches within the network:
Marianne Lafont (INCIT, Angers) spoke about the dissemination of mycobacterial extracellular vesicles using Mycobacterium ulcerans as a study model.
Soizig Rouilliaux (HIFIH, Angers) shared his work on optimization of characterization protocols for EVs from the intestinal microbiota and their role in the development of steatohepatitis associated with metabolic dysfunction
Hajar Yaakoub (PhAN, Nantes) presented characterization results on the Fecal EVs, from a defined intestinal microbiota model, paving the way for better standardization of this type of approach.
Juliana Guimaraes Laguna (STLO, Rennes) explored the immunomodulatory effects of extracellular vesicles derived from probiotic bacteria Propionibacterium freudenreichii , highlighting their mechanism of interaction with host cells.
This session illustrated the wealth of themes covered by the network members, ranging from infectious diseases to the modulation of the microbiota, including fundamental research on the mechanisms of action of EVs.
A public vote was held following the oral presentations to select the best scientific presentation of the day. Soizig Rouilliaux was elected the winner, praised for the quality and clarity of her presentation.
Keynote Lecture – An International Perspective
The afternoon began with a plenary conference by An Hendrix (Ghent University, Belgium), international expert in the field, entitled: “Extracellular vesicles: from technology to biomedical application”.
His intervention made it possible to make a state of the art of EV technologies and to highlight the translational avenues towards clinical applications, while recalling the importance of standardization and best practices. A strong moment, which nourished the network's reflections.
Future of GO-EV and open discussion
The day concluded with a prospective time led by Guillaume Van Niel (CRCI2NA, Nantes), who presented the future Zebrafish core facility and its possibilities for in vivo studies for EVs. His presentation highlighted the interest of this model and the advantages of its use in the context of EVs. He did this by drawing on numerous existing publications and the work already carried out in this field.
A collaborative and poster session
Throughout the day, break times, moments around posters and informal discussions encouraged inter-team connections, strengthened the collective dynamic and underlined the importance of this type of event to jointly advance research on EVs.
Times of conviviality around the posters provided an opportunity to discover the projects of young researchers and to encourage informal discussions. This session was introduced by “poster teasers” to encourage people to come and discover their work.
During the dedicated session, participants were also invited to vote for the best scientific poster presented.
Juliette Jamoneau won this distinction, highlighting the relevance of her work and the quality of its visual enhancement.
Thanks
We warmly thank theUniversité d'Angers as well as our patron Beckman Coulter for their invaluable support. A big thank you also to all the speakers for the quality of their presentations, and to all the participants for their presence and commitment throughout the day.
This meeting once again demonstrated the richness of the discussions, the dynamism, and the collaborative spirit that drive the GO-EV network. We look forward to continuing this wonderful momentum with our upcoming initiatives.
Find network highlights and upcoming events on our Agenda page.
And to make sure you don't miss anything, follow GO-EV news on our LinkedIn page !
Local Organizing Committee
Soazig Le Lay, EV-Link, the Thorax Institute & SFR ICAT, Nantes-Angers
Lionel Fizanne, HIFIH, Angers
Josy Froger, EV-Link, the Thorax Institute & SFR ICAT, Nantes-Angers
Hélène Pailhoriès, HIFIH, Angers
Catherine Guillet, PACeM, Angers
Jérôme Cayon, PACeM, Angers
Arnaud Chevrollier, SCIAM and MitoVasc-MitoLab, Angers
François Guillonneau, Prot'ICO, Angers
Article written by Mehdi Tazi (GO-EV Network Coordinator)
